The No 7 dial sight, MK. II

Convergent Synthesis of Menaquinone‐7 (MK-7)

A practical synthesis of menaquinone-7 (MK-7, vitamin K2) in the all-trans form was designed. Stereoselective synthesis of MK-7 was achieved through a “1 + 6” convergent strategy by condensation of two building blocks, menadione monoprenyl derivative (fragment “1”) with hexaprenyl bromide (fragment “6”, 82%). Pd-catalyzed desulfonation with LiEt3BH (78%) was followed by oxidation of the hydroqu...

vision 2020: the right to sight in 7 years?

editorial/no abstract

Cover vol.7, no.3

Paget's Osteosarcoma — no Cure in Sight

UNLABELLED Purpose Paget' s osteosarcoma has a fearful reputation with a quoted survival of at best 5% at 5 years.We therefore reviewed our experience of 26 patients treated over the last 25 years using modern staging and limb salvage techniques to see if there had been any improvement in survival. SUBJECTS We identified 26 patients on the Royal Orthopaedic Hospital Oncological database with ...

Graphs with no 7-wheel subdivision, version II

The subgraph homeomorphism problem, SHP(H), has been shown to be polynomial-time solvable for any fixed pattern graph H, but practical algorithms have been developed only for a few specific pattern graphs. Among these are the wheels with four, five, and six spokes. This paper examines the subgraph homeomorphism problem where the pattern graph is a wheel with seven spokes, and gives a result tha...